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Issue 20, 2014
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Aqueous organocatalyzed aldol reaction of glyoxylic acid for the enantioselective synthesis of α-hydroxy-γ-keto acids

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Abstract

N-Tosyl-(Sa)-binam-L-prolinamide is an efficient catalyst for the aqueous aldol reaction, between glyoxylic acid, as monohydrate or aqueous solution, and ketones. This reaction led to the formation of chiral α-hydroxy-γ-keto carboxylic acids in high levels of diastereo- and enantioselectivities achieving mainly anti aldol products.

Graphical abstract: Aqueous organocatalyzed aldol reaction of glyoxylic acid for the enantioselective synthesis of α-hydroxy-γ-keto acids

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Publication details

The article was received on 18 Nov 2013, accepted on 18 Dec 2013 and first published on 19 Dec 2013


Article type: Communication
DOI: 10.1039/C3RA46800C
Citation: RSC Adv., 2014,4, 9963-9966
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    Aqueous organocatalyzed aldol reaction of glyoxylic acid for the enantioselective synthesis of α-hydroxy-γ-keto acids

    F. J. N. Moles, G. Guillena and C. Nájera, RSC Adv., 2014, 4, 9963
    DOI: 10.1039/C3RA46800C

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