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Issue 3, 2014
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Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

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Abstract

Multifunctional nanoparticles based on a green emitting, hydrophobic conjugated polymer, poly[(9,9-bis{propeny}fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1,3}-thiodiazole)] (PPFBT), that acts both as a fluorescent reporter and a matrix to accommodate an anti-cancer compound, camptothecin (CPT), were prepared, characterized and their potential as a fluorescent probe for cell imaging and as a drug delivery vehicle were evaluated via in vitro cell assays. The cell viability of human hepatocellular carcinoma cell line (Huh7) was investigated in the absence and presence of CPT with sulforhodamine B (SRB) and real-time cell electronic sensing (RT-CES) cytotoxicity assays.

Graphical abstract: Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

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Supplementary files

Article information


Submitted
14 Sep 2013
Accepted
10 Oct 2013
First published
10 Oct 2013

RSC Adv., 2014,4, 1302-1309
Article type
Paper

Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

Ö. Gezici, İ. Durmaz, E. Bilget Güven, Ö. Ünal, A. Özgün, R. Cetin-Atalay and D. Tuncel, RSC Adv., 2014, 4, 1302
DOI: 10.1039/C3RA45120H

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