Issue 28, 2014
From the journal:

RSC Advances

Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity†

Walter R. Martínez,a   Gardenia C. G. Militão,b   Teresinha G. da Silva,c   Ricardo O. Silvaa  and  Paulo H. Menezes*a  

* Corresponding authors

a Universidade Federal de Pernambuco – Depto. Química Fundamental, Av. Jornalista Anibal Fernandes s/n, Recife, PE, Brazil
E-mail: paulo.menezes@pq.cnpq.br
Fax: +55-81-2126-8442

b Universidade Federal de Pernambuco – Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil

c Universidade Federal de Pernambuco – Departamento de Antibióticos, CCB, Cidade Universitária, Recife, PE, Brazil

Abstract

A new method for the synthesis of [3,1]-benzothiazepines and [3,1]-benzoxazepines from the reaction of C-allylanilines and isothiocyanates or isocyanates without the need for the isolation of any intermediate is described. The compounds were obtained in good to moderate yields and some exhibited cytotoxic activity against tumor cell lines.

Graphical abstract: Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

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Article information

DOI
https://doi.org/10.1039/C3RA44937H
Article type
Communication
Submitted
06 Sep 2013
Accepted
12 Mar 2014
First published
12 Mar 2014

RSC Adv., 2014,4, 14715-14718

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Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

W. R. Martínez, G. C. G. Militão, T. G. da Silva, R. O. Silva and P. H. Menezes, RSC Adv., 2014, 4, 14715 DOI: 10.1039/C3RA44937H

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