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Issue 9, 2014
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Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

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Abstract

The flow regime was implemented as a non-chemical alternative for the reaction control and detrimental acid byproduct sequestration in transition metal catalyzed cross-coupling reactions. The concept was illustrated on the Sonogashira reaction and resulted in a non-basic version of the cross-coupling protocols.

Graphical abstract: Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

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Supplementary files

Article information


Submitted
18 Jul 2014
Accepted
14 Aug 2014
First published
26 Aug 2014

Org. Chem. Front., 2014,1, 1067-1071
Article type
Research Article
Author version available

Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

S. Voltrova and J. Srogl, Org. Chem. Front., 2014, 1, 1067
DOI: 10.1039/C4QO00198B

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