Issue 8, 2014
From the journal:

Organic Chemistry Frontiers

Generation of 1-(trifluoromethyl)isoquinolines via a copper-catalyzed reaction of isoquinoline-N-oxide with Togni reagent†

Congbin Fan,‡ab   Junjie Song,‡a   Guanyinsheng Qiu,b   Gang Liu*a  and  Jie Wu*b  

* Corresponding authors

a Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University, Nanchang 330013, China
E-mail: liugang0926@163.com

b Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: jie_wu@fudan.edu.cn
Fax: +86 21 6564 1740
Tel: +86 21 6510 2412

Abstract

Isoquinoline-N-oxides react with Togni reagent catalyzed by copper(II) triflate, leading to 1-(trifluoromethyl)isoquinolines in good yields. The reaction proceeds smoothly under mild conditions with high efficiency.

Graphical abstract: Generation of 1-(trifluoromethyl)isoquinolines via a copper-catalyzed reaction of isoquinoline-N-oxide with Togni reagent

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4QO00173G
Article type
Research Article
Submitted
24 Jun 2014
Accepted
12 Jul 2014
First published
15 Jul 2014

Org. Chem. Front., 2014,1, 924-928

Permissions

Request permissions

Generation of 1-(trifluoromethyl)isoquinolines via a copper-catalyzed reaction of isoquinoline-N-oxide with Togni reagent

C. Fan, J. Song, G. Qiu, G. Liu and J. Wu, Org. Chem. Front., 2014, 1, 924 DOI: 10.1039/C4QO00173G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements