Issue 3, 2014
From the journal:

Organic Chemistry Frontiers

Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA†

Yuqi Chen,a   Shengyong Yan,a   Libo Yuan,a   Yimin Zhou,a   Yanyan Song,a   Heng Xiao,a   Xiaocheng Weng*a  and  Xiang Zhou*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: xzhou@whu.edu.cn, xcweng@whu.edu.cn
Fax: (+)86-27-68756663
Tel: (+)86-27-68756663

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, P. R. China

Abstract

A squarylium dye TSQ1 shows a remarkable fluorescence enhancement selectivity for the G-quadruplex DNA structure against duplex DNA, it can be distinguished even by the naked eye. What is more important, TSQ1 did not induce the G-rich sequence folding into G-quadruplex structure which means TSQ1 can be used to detect G-quadruplex structures in cells.

Graphical abstract: Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA

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Article information

DOI
https://doi.org/10.1039/C3QO00048F
Article type
Research Article
Submitted
21 Nov 2013
Accepted
07 Jan 2014
First published
06 Feb 2014

Org. Chem. Front., 2014,1, 267-270

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Nonlinear optical dye TSQ1 as an efficiently selective fluorescent probe for G-quadruplex DNA

Y. Chen, S. Yan, L. Yuan, Y. Zhou, Y. Song, H. Xiao, X. Weng and X. Zhou, Org. Chem. Front., 2014, 1, 267 DOI: 10.1039/C3QO00048F

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