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Issue 9, 2016
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Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger

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Abstract

Antifreeze (glyco)proteins (AF(G)Ps) have potent ice recrystallisation inhibition (IRI) activity – a desirable phenomenon in applications such as cryopreservation, frozen food and more. In Nature AF(G)P activity is regulated by protein expression levels in response to an environmental stimulus; temperature. However, this level of regulation is not possible in synthetic systems. Here, a synthetic macromolecular mimic is introduced, using supramolecular assembly to regulate activity. Catechol-terminated poly(vinyl alcohol) was synthesised by RAFT polymerization. Upon addition of Fe3+, larger supramolecular star polymers form by assembly with two or three catechols. This increase in molecular weight effectively ‘switches on’ the IRI activity and is the first example of external control over the function of AFP mimetics. This provides a simple but elegant solution to the challenge of external control of AFP-mimetic function.

Graphical abstract: Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger

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Publication details

The article was received on 07 Dec 2015, accepted on 28 Jan 2016 and first published on 29 Jan 2016


Article type: Communication
DOI: 10.1039/C5PY01948F
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Polym. Chem., 2016,7, 1701-1704

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    Activation of ice recrystallization inhibition activity of poly(vinyl alcohol) using a supramolecular trigger

    D. J. Phillips, T. R. Congdon and M. I. Gibson, Polym. Chem., 2016, 7, 1701
    DOI: 10.1039/C5PY01948F

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