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Issue 24, 2014
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Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

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Abstract

A synthetic method for thermoresponsive, glycerol based nanogels has been developed. The nanogels were synthesized by nanoprecipitation of the orthogonally functionalized macromonomers and their gelation in water. The crosslinking points were generated by strain promoted azide–alkyne cycloaddition which enabled the in situ encapsulation of Doxorubicin HCl. The mild and surfactant free reaction conditions make these nanogels ideal candidates for biomedical applications.

Graphical abstract: Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

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Publication details

The article was received on 27 Aug 2014, accepted on 12 Sep 2014 and first published on 15 Sep 2014


Article type: Communication
DOI: 10.1039/C4PY01186D
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Polym. Chem., 2014,5, 6909-6913
  • Open access: Creative Commons BY-NC license
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    Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives

    M. Giulbudagian, M. Asadian-Birjand, D. Steinhilber, K. Achazi, M. Molina and M. Calderón, Polym. Chem., 2014, 5, 6909
    DOI: 10.1039/C4PY01186D

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