Yuan Zhao, Bin Yang, Yaling Zhang, Shiqi Wang, Changkui Fu, Yen Wei and Lei Tao
Polym. Chem., 2014,5, 6656-6661
DOI:
10.1039/C4PY00995A,
Communication
Theranostic combinations usually contain an imaging, a therapeutic and a cloaking component to simultaneously fulfil diagnostic and therapeutic functions. Using upgraded PEGylation technology, a straightforward one-pot strategy based on thiolactone ring-opening has been developed to facilely synthesize a multifunctional PEGylation agent, fluorescent protein-reactive poly(ethylene glycol) (PEG), which can subsequently react with a model therapeutic protein to form a fluorescent PEGylated protein as a model of sophisticated theranostic combinations.