Dynamic uptake and release from poly(methacryloyl hydrazide) microgel particles through reversible hydrazide-aldehyde chemistry

The synthesis of poly(methacryloyl hydrazide) microgels via dispersion polymerization for the controlled release of carbonyl containing compounds is described. The kinetics of the dynamic reaction that occurs between the hydrazide containing colloidal particles and aldehyde compounds are explored for aqueous dispersions and it is shown that the aldehyde release profiles at conditions of physiological significance indicate a dynamic balance between the reaction components providing a route to sustained release of functional molecules.