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Issue 19, 2014
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Zwitterionic poly(2-oxazoline)s as promising candidates for blood contacting applications

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Abstract

We report the synthesis of highly hemo- and cytocompatible zwitterionic 2-oxazoline-based poly(sulfobetaine)s and poly(carboxybetaine)s, which demonstrate beneficial anticoagulant activity. The polymers were obtained by thiol–ene photoaddition of a tertiary amine-containing thiol onto an alkene-containing precursor copoly(2-oxazoline), followed by betainization with 1,3-propansultone and β-propiolactone. The polymers and their intermediates were characterized by means of 1H NMR spectroscopy and size exclusion chromatography. The influence of the zwitterionic polymers on the aggregation and hemolysis of erythrocytes, the whole blood viscosity, the platelet and complement activation as well as the blood coagulation has been studied in detail. In addition, the cytotoxicity of the materials has been evaluated. It was found that the zwitterionic POx show no negative interactions with blood. Moreover, anticoagulant activity via the intrinsic and/or the common coagulation pathway was observed. The high hemocompatibility and the low cytotoxicity as well as the beneficial anticoagulant activity of the presented zwitterionic poly(2-oxazoline)s demonstrate their potential for the use in biomedical applications.

Graphical abstract: Zwitterionic poly(2-oxazoline)s as promising candidates for blood contacting applications

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Supplementary files

Article information


Submitted
26 Mar 2014
Accepted
15 May 2014
First published
21 May 2014

Polym. Chem., 2014,5, 5751-5764
Article type
Paper
Author version available

Zwitterionic poly(2-oxazoline)s as promising candidates for blood contacting applications

L. Tauhardt, D. Pretzel, K. Kempe, M. Gottschaldt, D. Pohlers and U. S. Schubert, Polym. Chem., 2014, 5, 5751
DOI: 10.1039/C4PY00434E

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