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Issue 11, 2014
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An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

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Abstract

Polyester nanosponges were prepared with varied degrees of crosslinking densities of ∼4%, ∼7% and ∼10% and an average nanoscopic size of 100 nm. The crosslinking density and the influence towards the release kinetics of paclitaxel, a BCS class IV drug, for individual particles and a mixture of particles with two different crosslinking densities are investigated in buffer and gastrointestinal fluid to show fully adjustable release rates suitable for intravenous and oral delivery.

Graphical abstract: An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

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Supplementary files

Article information


Submitted
13 Feb 2014
Accepted
31 Mar 2014
First published
01 Apr 2014

Polym. Chem., 2014,5, 3551-3554
Article type
Communication

An assessment of nanosponges for intravenous and oral drug delivery of BCS class IV drugs: Drug delivery kinetics and solubilization

D. M. Stevens, K. A. Gilmore and E. Harth, Polym. Chem., 2014, 5, 3551
DOI: 10.1039/C4PY00207E

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