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Issue 12, 2014
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Electrochemical deposition of polypeptides: bio-based covering materials for surface design

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Abstract

A simple and efficient approach for the electrochemical deposition of polypeptides as bio-based covering materials for surface design is described. The method involves N-carboxyanhydride (NCA) ring-opening polymerization from its precursor to form a thiophene-functionalized polypeptide macromonomer (T-Pala), followed by electropolymerization. The obtained conducting polymer, namely polythiophene-g-polyalanine (PT-Pala), was characterized and utilized as a matrix for biomolecule attachment. The biosensing applicability of PT-Pala was also investigated by using glucose oxidase (GOx) as a model enzyme to detect glucose. The designed biosensor showed a very good linearity for 0.01–1.0 mM glucose. Finally, the antimicrobial activities of newly synthesized T-Pala and PT-Pala were also evaluated by using the disc diffusion method.

Graphical abstract: Electrochemical deposition of polypeptides: bio-based covering materials for surface design

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Supplementary files

Article information


Submitted
19 Jan 2014
Accepted
11 Mar 2014
First published
12 Mar 2014

Polym. Chem., 2014,5, 3929-3936
Article type
Paper
Author version available

Electrochemical deposition of polypeptides: bio-based covering materials for surface design

H. Akbulut, M. Yavuz, E. Guler, D. O. Demirkol, T. Endo, S. Yamada, S. Timur and Y. Yagci, Polym. Chem., 2014, 5, 3929
DOI: 10.1039/C4PY00079J

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