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Issue 13, 2014
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Fully biodegradable antibacterial hydrogels via thiol–ene “click” chemistry

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Abstract

In this work, fully biodegradable antimicrobial hydrogels were prepared facilely via a thiol–ene “click” reaction under human physiological conditions using multifunctional poly(ethylene glycol) (PEG) derivatives as precursors. Water soluble and degradable PEG derivatives with multi-enes and multi-thiols, respectively, were synthesized by polycondensation of oligo(ethylene glycol) (OEG) with “clickable” monomers. Ammonium groups with long alkyl chains were incorporated into one of the precursors covalently, using dodecyl bis(2-hydroxyethyl) methylammonium chloride as a comonomer. Proton nuclear magnetic resonance (1H-NMR) spectroscopy, gel permeation chromatography (GPC) and Fourier transform infrared spectroscopy (FT-IR) were used to characterize the precursors and hydrogels. These types of cationic PEG-type hydrogels showed strong antibacterial abilities against both Gram-negative and Gram-positive bacteria due to the ammonium moieties. Moreover, the hydrogel with fewer ammonium moieties still possessed significant antibacterial abilities, but low toxicity, and has the potential to be used as a medical material.

Graphical abstract: Fully biodegradable antibacterial hydrogels via thiol–ene “click” chemistry

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Publication details

The article was received on 10 Jan 2014, accepted on 05 Mar 2014 and first published on 06 Mar 2014


Article type: Paper
DOI: 10.1039/C4PY00030G
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Citation: Polym. Chem., 2014,5, 4002-4008

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    Fully biodegradable antibacterial hydrogels via thiol–ene “click” chemistry

    H. Du, G. Zha, L. Gao, H. Wang, X. Li, Z. Shen and W. Zhu, Polym. Chem., 2014, 5, 4002
    DOI: 10.1039/C4PY00030G

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