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Issue 8, 2014
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Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

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Abstract

We report here the preparation of dual-temperature and pH responsive (ethylene glycol)-based nanogels via the reversible addition–fragmentation chain transfer (RAFT) polymerization under aqueous conditions. The core–shell structures of the nanogels were composed of 2-(2-methoxyethoxy)ethyl methacrylate (MEO2MA), oligo(ethylene glycol) methacrylate (OEGMA), and di(ethylene glycol) dimethacrylate as a cross-linker. Both the core and shell structures of the nanogels showed a lower critical solution temperature (LCST). Interestingly, the LCST of the shell was strongly affected by the solution pH and salt concentration due to the presence of carboxyl groups at the nanogel surface. These dual temperature and pH responsive nanogels are expected to be non-toxic and therefore can be used as novel biomaterials for drug delivery applications.

Graphical abstract: Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

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Publication details

The article was received on 26 Dec 2013, accepted on 25 Jan 2014 and first published on 28 Jan 2014


Article type: Paper
DOI: 10.1039/C3PY01772A
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Citation: Polym. Chem., 2014,5, 3061-3070

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    Dual-temperature and pH responsive (ethylene glycol)-based nanogels via structural design

    Y. Kotsuchibashi and R. Narain, Polym. Chem., 2014, 5, 3061
    DOI: 10.1039/C3PY01772A

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