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Issue 6, 2014
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Enzyme-catalyzed ring-opening polymerization of ε-caprolactone using alkyne functionalized initiators

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Abstract

Well-defined poly(caprolactone)s were generated using alkyne-based initiating systems catalyzed by Candida antarctica Lipase B (CALB). Propargyl alcohol and 4-dibenzocyclooctynol (DIBO) were shown to efficiently initiate the polymerizations under metal free conditions and yielded 4 to 24 KDa polymers with relatively narrow molecular mass distribution. The alkyne bonds in the strained and unstrained initiating systems survived the polymerization conditions and the purification process. The resulting bonds can be sequentially functionalized post-polymerization using metal free and copper catalyzed click chemistry conditions.

Graphical abstract: Enzyme-catalyzed ring-opening polymerization of ε-caprolactone using alkyne functionalized initiators

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Supplementary files

Article information


Submitted
01 Nov 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

Polym. Chem., 2014,5, 1891-1896
Article type
Paper

Enzyme-catalyzed ring-opening polymerization of ε-caprolactone using alkyne functionalized initiators

M. Castano, J. Zheng, J. E. Puskas and M. L. Becker, Polym. Chem., 2014, 5, 1891
DOI: 10.1039/C3PY01536J

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