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Issue 5, 2014
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Recent trends in the design of anticancer polymer prodrug nanocarriers

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Abstract

Nanocarriers based on polymers have attracted much attention to perform drug delivery, especially in cancer therapy. Although significant advances have been reported, important obstacles still remain with the use of encapsulated anticancer drugs in polymer nanoparticles (e.g., ‘burst release’, poor drug loading, low miscibility of certain drugs with the polymer matrix). To solve these issues, synthetic strategies orientated toward the prodrug approach, whereby the drug is covalently linked to the polymer scaffold, have been investigated and are detailed in the present review. It will focus on recent synthetic strategies to achieve drug–polymer conjugate nanoassemblies as well as their biological evaluations.

Graphical abstract: Recent trends in the design of anticancer polymer prodrug nanocarriers

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Article information


Submitted
02 Oct 2013
Accepted
25 Oct 2013
First published
29 Oct 2013

Polym. Chem., 2014,5, 1529-1544
Article type
Review Article

Recent trends in the design of anticancer polymer prodrug nanocarriers

V. Delplace, P. Couvreur and J. Nicolas, Polym. Chem., 2014, 5, 1529
DOI: 10.1039/C3PY01384G

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