Issue 3, 2014

Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

Abstract

Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG8) building block to give MeO–EG24–OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

Graphical abstract: Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

Supplementary files

Article information

Article type
Communication
Submitted
30 Sep 2013
Accepted
23 Oct 2013
First published
24 Oct 2013

Polym. Chem., 2014,5, 694-697

Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

G. Székely, M. Schaepertoens, P. R. J. Gaffney and A. G. Livingston, Polym. Chem., 2014, 5, 694 DOI: 10.1039/C3PY01367G

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