Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 1, 2014
Previous Article Next Article

Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

Author affiliations

Abstract

The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a ‘solubility release catch’ at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an ‘isothermal’ response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products.

Graphical abstract: Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

Back to tab navigation

Supplementary files

Article information


Submitted
24 Jul 2013
Accepted
14 Aug 2013
First published
15 Aug 2013

Polym. Chem., 2014,5, 126-131
Article type
Paper

Glutathione-triggered disassembly of isothermally responsive polymer nanoparticles obtained by nanoprecipitation of hydrophilic polymers

D. J. Phillips, J. P. Patterson, R. K. O'Reilly and M. I. Gibson, Polym. Chem., 2014, 5, 126
DOI: 10.1039/C3PY00991B

Social activity

Search articles by author

Spotlight

Advertisements