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Issue 4, 2014
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Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer–protein conjugates with transient solubility

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Abstract

Via a smart combination of temperature-responsive and acid labile acetal monomers, copolymers are obtained with à la carte lower critical solution temperature behavior. RAFT copolymerization of these monomers using, respectively, a PEG-functionalized or amine-reactive NHS-functionalized chain transfer agent allows designing of micelles and polymer–protein conjugates with transient solubility properties within a physiologically relevant window.

Graphical abstract: Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer–protein conjugates with transient solubility

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Article information


Submitted
22 Jul 2013
Accepted
13 Aug 2013
First published
14 Aug 2013

Polym. Chem., 2014,5, 1140-1144
Article type
Paper

Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer–protein conjugates with transient solubility

Q. Zhang, N. Vanparijs, B. Louage, B. G. De Geest and R. Hoogenboom, Polym. Chem., 2014, 5, 1140
DOI: 10.1039/C3PY00971H

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