Huanrui Zhang, Baomin Wang, Longchen Cui, Ying Li, Jingping Qu and Yuming Song
Org. Biomol. Chem., 2014,12, 9097-9100
DOI:
10.1039/C4OB01921K,
Communication
We report a highly efficient approach to constructing chiral N,S-acetals using 5-substituted rhodanines as sulfur-bound pronucleophiles catalyzed by natural cinchona alkaloids quinine or quinidine. This α-amination reaction has a broad substrate scope, and the products featuring both rhodanine and N,S-acetal structural motifs were obtained in high yields and excellent enantioselectivities.
