Jump to main content
Jump to site search

Issue 47, 2014
Previous Article Next Article

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

Author affiliations

Abstract

An efficient method for the C3-glucuronidation of bile acids is developed under flow conditions. A modular mesoreactor assisted flow set-up was combined with statistical design of experiments to speed up the optimization of the Koenigs–Knorr reaction in terms of yield, regioselectivity, costs, as well as technical and practical standpoints. Using the optimal conditions, selective glucuronidation of naturally occurring bile acids was successfully achieved offering a new, valuable route to C3-glucuronidated bile acids useful for biological, diagnostic and PK/ADMET investigations.

Graphical abstract: Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

Back to tab navigation

Supplementary files

Article information


Submitted
09 Sep 2014
Accepted
26 Sep 2014
First published
26 Sep 2014

Org. Biomol. Chem., 2014,12, 9592-9600
Article type
Paper

Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs–Knorr reaction optimization

S. Mostarda, P. Filipponi, R. Sardella, F. Venturoni, B. Natalini, R. Pellicciari and A. Gioiello, Org. Biomol. Chem., 2014, 12, 9592
DOI: 10.1039/C4OB01911C

Social activity

Search articles by author

Spotlight

Advertisements