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Issue 47, 2014
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An efficient reagent for covalent introduction of alkynes into proteins

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Abstract

A cheap and bench-stable reagent was synthesized for direct and covalent introduction of alkynes into tyrosine of target proteins, which can be further modified based on click reaction to achieve fluorescence labelling or PEGylation. This reagent should be a generally useful toolbox for chemical biology and biomaterials.

Graphical abstract: An efficient reagent for covalent introduction of alkynes into proteins

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Publication details

The article was received on 02 Sep 2014, accepted on 15 Oct 2014 and first published on 16 Oct 2014


Article type: Communication
DOI: 10.1039/C4OB01873G
Org. Biomol. Chem., 2014,12, 9528-9531

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    An efficient reagent for covalent introduction of alkynes into proteins

    J. Zhang, D. Ma, D. Du, Z. Xi and L. Yi, Org. Biomol. Chem., 2014, 12, 9528
    DOI: 10.1039/C4OB01873G

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