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Issue 39, 2014
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Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones

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Abstract

This communication reports a significant breakthrough on the novel catalytic amide allylation to the acyclic α-ketoester systems, achieving satisfactorily high yields and extremely high levels of the asymmetric induction to allow for highly enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones.

Graphical abstract: Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones

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Publication details

The article was received on 17 Jul 2014, accepted on 12 Aug 2014 and first published on 12 Aug 2014


Article type: Communication
DOI: 10.1039/C4OB01508H
Org. Biomol. Chem., 2014,12, 7686-7689

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    Catalytic amide allylation of α-ketoesters: extremely high enantioselective synthesis of ester functionalised α-methylene-γ-butyrolactones

    M. Takahashi, Y. Murata, M. Ishida, F. Yagishita, M. Sakamoto, T. Sengoku and H. Yoda, Org. Biomol. Chem., 2014, 12, 7686
    DOI: 10.1039/C4OB01508H

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