Issue 37, 2014
From the journal:

Organic & Biomolecular Chemistry

Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives†

Michael A. Bertucci,a   Stephen J. Leeb  and  Michel R. Gagné*a  

* Corresponding authors

a Department of Chemistry, University of North Carolina at Chapel Hill, Campus Box 3290, Caudill and Kenan Laboratories, Chapel Hill, NC, USA
E-mail: mgagne@unc.edu

b US Army Research Office, P.O. Box 12211, Research Triangle Park, NC, USA

Abstract

A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.

Graphical abstract: Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

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Article information

DOI
https://doi.org/10.1039/C4OB01156B
Article type
Communication
Submitted
04 Jun 2014
Accepted
12 Aug 2014
First published
12 Aug 2014

Org. Biomol. Chem., 2014,12, 7197-7200

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Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

M. A. Bertucci, S. J. Lee and M. R. Gagné, Org. Biomol. Chem., 2014, 12, 7197 DOI: 10.1039/C4OB01156B

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