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Issue 33, 2014
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Amino acid chirons: a tool for asymmetric synthesis of heterocycles

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Abstract

As a result of their easy availability in enantiomerically enriched form and their possession of synthetically transformable diverse functional groups, amino acids have been extensively used by synthetic organic and medicinal chemists as a chiral pool for access to heterocycles (monocycles, bicycles or polycycles, either bridged or fused). This review describes the syntheses of diverse asymmetric heterocycles with various membered rings (n = 3–9) followed by benzo or heteroannulated ones, for the period from 1996 to Dec. 2013. It details solution phase synthetic methodologies in which the naturally occurring α-amino acid is incorporated, totally or partially, into the final product.

Graphical abstract: Amino acid chirons: a tool for asymmetric synthesis of heterocycles

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Publication details

The article was received on 07 May 2014, accepted on 17 Jun 2014 and first published on 17 Jun 2014


Article type: Review Article
DOI: 10.1039/C4OB00943F
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Org. Biomol. Chem., 2014,12, 6297-6339

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    Amino acid chirons: a tool for asymmetric synthesis of heterocycles

    P. Singh, K. Samanta, S. K. Das and G. Panda, Org. Biomol. Chem., 2014, 12, 6297
    DOI: 10.1039/C4OB00943F

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