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Issue 31, 2014
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Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells

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Abstract

We have efficiently synthesized albiziabioside A (1) together with its six disaccharide analogues through a linear synthesis, and evaluated their cytotoxicity against six different skin cancer cells. All of the analogues showed weak cytotoxicity, with the exception of compound 1, which exhibited strong cytotoxicity against A375 cells. Albiziabioside A can induce cell cycle arrest in both the S and G2/M phases. Moreover, albiziabioside A can induce A375 cell apoptosis via mitochondrial pathways involving a caspase cascade. These results provide for the first time a basic mechanism for the anticancer activity of 1.

Graphical abstract: Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells

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Supplementary files

Article information


Submitted
29 Apr 2014
Accepted
11 Jun 2014
First published
11 Jun 2014

Org. Biomol. Chem., 2014,12, 5928-5935
Article type
Paper

Synthesis and evaluation of the anticancer activity of albiziabioside A and its analogues as apoptosis inducers against human melanoma cells

G. Wei, S. Wang, S. Cui, J. Guo, Y. Liu, Y. Liu and M. Cheng, Org. Biomol. Chem., 2014, 12, 5928
DOI: 10.1039/C4OB00874J

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