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Issue 30, 2014
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Synthesis of functionalized chromones through sequential reactions in aqueous media

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Abstract

An efficient sequential four-component reaction of chromone carbaldehydes, Meldrum's acid, 4-hydroxyl coumarin or 6-methyl-4-hydroxyl-pyrone and primary alcohols is reported which leads to 5a–i in aqueous media. Replacing the primary alcohol with isopropyl alcohol and tert-butyl alcohol results in different products 10 and 11. The environmentally friendly features, good to high yields and easy work-up are advantages of this approach.

Graphical abstract: Synthesis of functionalized chromones through sequential reactions in aqueous media

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Article information


Submitted
22 Mar 2014
Accepted
29 May 2014
First published
29 May 2014

Org. Biomol. Chem., 2014,12, 5757-5765
Article type
Paper
Author version available

Synthesis of functionalized chromones through sequential reactions in aqueous media

S. Mehrparvar, S. Balalaie, M. Rabbanizadeh, F. Rominger and E. Ghabraie, Org. Biomol. Chem., 2014, 12, 5757
DOI: 10.1039/C4OB00618F

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