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Issue 26, 2014
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Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines

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Abstract

This article compares the diastereoselective epoxidation of acyclic and cyclic allylic alcohols, with the chemo- and diastereoselective olefinic oxidation of a range of acyclic and cyclic allylic amines. The diastereoselectivity in these systems is compared and a discussion about the origin of this high diastereocontrol is also presented. The ammonium directed epoxidation methodology has been extended to more complex substrates and representative applications of this protocol in natural product synthesis are also summarised.

Graphical abstract: Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines

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Article information


Submitted
22 Mar 2014
Accepted
16 May 2014
First published
23 May 2014

Org. Biomol. Chem., 2014,12, 4544-4549
Article type
Perspective

Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines

S. G. Davies, A. M. Fletcher and J. E. Thomson, Org. Biomol. Chem., 2014, 12, 4544
DOI: 10.1039/C4OB00616J

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