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The effect of aryl substitution on various aspects of the interconversion of ortho-hydroxychalcones and flavanones has been studied using multiple spectroscopic techniques. Derivatization of the core scaffold predictably alters the midpoint pH of this equilibration process suggesting its viability for application as a functional colorimetric molecular switch.

Graphical abstract: Impact of mono- and disubstitution on the colorimetric dynamic covalent switching chalcone/flavanone scaffold

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