Bo Su, Hui Zhang, Meng Deng and Qingmin Wang
Org. Biomol. Chem., 2014,12, 3616-3621
DOI:
10.1039/C4OB00200H,
Paper
A new asymmetric total synthesis of a phenanthroindolizidine alkaloid (S)-tylophorine is reported, which features a catalytic asymmetric allylation of aldehydes and an unexpected one-pot DMAP promoted isocyanate formation and Lewis acid catalyzed intramolecular cyclization reaction. In addition, White's direct C–H oxidation catalyst system converting monosubstituted olefins to linear allylic acetates was also employed for late-stage transformation.