Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2014
Previous Article Next Article

An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

Author affiliations

Abstract

The reaction of KSeOtBu with 2-iodo-arylbenzamides gave benzamide ring-substituted, quinine-derived isoselenazolones 1b–1d. The reaction of PhSH with ortho-methyl-substituted isoselenazolone 1b gave selenol 3b, which is oxidized by H2O2 to regenerate 1b. Isoselenazolone 1b shows a high rate (0.33 × 103 μM min−1) of oxidation of PhSH with H2O2, which is ∼103-fold more active than ebselen (1a) and ≥30-fold more active than the other isoselenazolones of this study. Compound 1b shows less inhibition of the growth of yeast cells than 1a.

Graphical abstract: An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

Back to tab navigation

Supplementary files

Article information


Submitted
04 Jan 2014
Accepted
08 Jan 2014
First published
08 Jan 2014

Org. Biomol. Chem., 2014,12, 1215-1219
Article type
Communication

An ebselen like catalyst with enhanced GPx activity via a selenol intermediate

S. J. Balkrishna, S. Kumar, G. K. Azad, B. S. Bhakuni, P. Panini, N. Ahalawat, R. S. Tomar, M. R. Detty and S. Kumar, Org. Biomol. Chem., 2014, 12, 1215
DOI: 10.1039/C4OB00027G

Social activity

Search articles by author

Spotlight

Advertisements