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A Cu-catalyzed new sequence involving the Ullmann type intermolecular C–C followed by an intramolecular C–N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.

Graphical abstract: A direct access to bioactive fused N-heterocyclic acetic acid derivatives

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