Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 7, 2014
Previous Article Next Article

Site-selected incorporation of 5-carboxymethylaminomethyl(-2-thio)uridine into RNA sequences by phosphoramidite chemistry

Author affiliations

Abstract

5-Carboxymethylaminomethyluridine (cmnm5U) and 5-carboxymethylaminomethyl-2-thiouridine (cmnm5s2U) are located at the wobble position in several cytosolic and mitochondrial tRNA sequences. In this paper, we report the first site-selected incorporation of cmnm5U and cmnm5s2U into RNA sequences by phosphoramidite chemistry on a CPG solid support. Trifluoroacetyl and 2-(trimethylsilyl)ethyl were selected for the protection of the amine and carboxyl functions, respectively.

Graphical abstract: Site-selected incorporation of 5-carboxymethylaminomethyl(-2-thio)uridine into RNA sequences by phosphoramidite chemistry

Back to tab navigation

Supplementary files

Article information


Submitted
19 Nov 2013
Accepted
17 Dec 2013
First published
18 Dec 2013

Org. Biomol. Chem., 2014,12, 1052-1056
Article type
Communication

Site-selected incorporation of 5-carboxymethylaminomethyl(-2-thio)uridine into RNA sequences by phosphoramidite chemistry

G. Leszczynska, J. Pięta, K. Wozniak and A. Malkiewicz, Org. Biomol. Chem., 2014, 12, 1052
DOI: 10.1039/C3OB42302F

Social activity

Search articles by author

Spotlight

Advertisements