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Issue 12, 2014
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Recent progress towards transition metal-catalyzed synthesis of γ-lactams

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Abstract

The occurrence of the γ-lactam unit in the framework of various biologically active compounds has greatly contributed to the design and development of new synthetic transformations to access this important structural motif. Among the numerous methods developed so far, those based on transition metal catalysis are of high value as they generally allow efficient and selective access to functionalized γ-lactams under rather mild reaction conditions. An overview of the recent advances in this field is presented herein. Metal-catalyzed processes are reviewed by highlighting their specificity and applicability, and the mechanistic rationale is presented where possible.

Graphical abstract: Recent progress towards transition metal-catalyzed synthesis of γ-lactams

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Article information


Submitted
04 Nov 2013
Accepted
30 Dec 2013
First published
06 Jan 2014

Org. Biomol. Chem., 2014,12, 1833-1845
Article type
Review Article
Author version available

Recent progress towards transition metal-catalyzed synthesis of γ-lactams

L. Ye, C. Shu and F. Gagosz, Org. Biomol. Chem., 2014, 12, 1833
DOI: 10.1039/C3OB42181C

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