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Issue 7, 2014
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Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol

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Abstract

Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.

Graphical abstract: Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol

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Publication details

The article was received on 02 Nov 2013, accepted on 23 Dec 2013 and first published on 02 Jan 2014


Article type: Communication
DOI: 10.1039/C3OB42174K
Org. Biomol. Chem., 2014,12, 1048-1051

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    Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol

    P. P. Daramwar, P. L. Srivastava, S. P. Kolet and H. V. Thulasiram, Org. Biomol. Chem., 2014, 12, 1048
    DOI: 10.1039/C3OB42174K

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