Issue 11, 2014
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed decarboxylative C3-acylation of free (N–H) indoles with α-oxocarboxylic acids†

Cuiping Wang,a   Shaoyan Wang,b   Hua Li,c   Jingbo Yan,b   Haijun Chi,a   Xichao Chenb  and  Zhiqiang Zhang*a  

* Corresponding authors

a Key Laboratory for Functional Material, Educational Department of Liaoning Province, University of Science and Technology Liaoning, Anshan, P. R. China
E-mail: zhangzhiqiang@ustl.edu.cn
Fax: +86 421 592 8009
Tel: +86 421 592 8009

b School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, P. R. China

c Jiang Yin Amber Biopharmaceutical Co., Ltd, Wuxi, P. R. China

Abstract

An efficient Cu-catalyzed decarboxylative C3-acylation of free (N–H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.

Graphical abstract: Copper-catalyzed decarboxylative C3-acylation of free (N–H) indoles with α-oxocarboxylic acids

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Article information

DOI
https://doi.org/10.1039/C3OB42171F
Article type
Communication
Submitted
02 Nov 2013
Accepted
19 Jan 2014
First published
22 Jan 2014

Org. Biomol. Chem., 2014,12, 1721-1724

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Copper-catalyzed decarboxylative C3-acylation of free (N–H) indoles with α-oxocarboxylic acids

C. Wang, S. Wang, H. Li, J. Yan, H. Chi, X. Chen and Z. Zhang, Org. Biomol. Chem., 2014, 12, 1721 DOI: 10.1039/C3OB42171F

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