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Issue 4, 2014
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Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents

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Abstract

Bromo- and thiomaleimides are shown to serve as highly effective quenchers of a covalently attached fluorophore. Reactions with thiols that lead to removal of the maleimide conjugation, or detachment of the fluorophore from the maleimide, result in ‘turn-on’ of the fluorescence. These reagents thus offer opportunities in thiol sensing and intracellular reporting.

Graphical abstract: Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents

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Article information


Submitted
28 Oct 2013
Accepted
25 Nov 2013
First published
25 Nov 2013

This article is Open Access

Org. Biomol. Chem., 2014,12, 557-560
Article type
Communication
Author version available

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence ‘turn-on’ reagents

J. Youziel, A. R. Akhbar, Q. Aziz, M. E. B. Smith, S. Caddick, A. Tinker and J. R. Baker, Org. Biomol. Chem., 2014, 12, 557
DOI: 10.1039/C3OB42141D

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