An intramolecular electrophilic ipso-iodocyclization of N-benzyl-N-(1-naphthyl)propiolamides combined with the Friedel–Crafts-type reaction for the synthesis of complex polycyclic lactams is reported. The resulting iodinated cyclization product can provide a very useful handle for further structural manipulation.
L. Wang, H. Zhu, Y. Qiu, X. Liu and Y. Liang, Org. Biomol. Chem., 2014, 12, 643 DOI: 10.1039/C3OB42020E
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