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Issue 4, 2014
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2-Arylacetic anhydrides as ammonium enolate precursors

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Abstract

Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition–lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and >99% ee).

Graphical abstract: 2-Arylacetic anhydrides as ammonium enolate precursors

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Publication details

The article was received on 12 Sep 2013, accepted on 20 Nov 2013 and first published on 29 Nov 2013


Article type: Paper
DOI: 10.1039/C3OB41869C
Citation: Org. Biomol. Chem., 2014,12, 624-636

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    2-Arylacetic anhydrides as ammonium enolate precursors

    L. C. Morrill, L. A. Ledingham, J. Couturier, J. Bickel, A. D. Harper, C. Fallan and A. D. Smith, Org. Biomol. Chem., 2014, 12, 624
    DOI: 10.1039/C3OB41869C

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