Jump to main content
Jump to site search

Issue 4, 2014
Previous Article Next Article

2-Arylacetic anhydrides as ammonium enolate precursors

Author affiliations

Abstract

Readily prepared 2-arylacetic anhydrides act as convenient ammonium enolate precursors in isothiourea (HBTM-2.1)-mediated catalytic asymmetric intermolecular Michael addition–lactonisation processes, giving diverse synthetic building blocks in good yield with high diastereo- and enantiocontrol (up to 98 : 2 dr and >99% ee).

Graphical abstract: 2-Arylacetic anhydrides as ammonium enolate precursors

Back to tab navigation

Supplementary files

Article information


Submitted
12 Sep 2013
Accepted
20 Nov 2013
First published
29 Nov 2013

Org. Biomol. Chem., 2014,12, 624-636
Article type
Paper

2-Arylacetic anhydrides as ammonium enolate precursors

L. C. Morrill, L. A. Ledingham, J. Couturier, J. Bickel, A. D. Harper, C. Fallan and A. D. Smith, Org. Biomol. Chem., 2014, 12, 624
DOI: 10.1039/C3OB41869C

Social activity

Search articles by author

Spotlight

Advertisements