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Issue 22, 2014
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Effect of nanovaccine chemistry on humoral immune response kinetics and maturation

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Abstract

Acute respiratory infections represent a significant portion of global morbidity and mortality annually. There is a critical need for efficacious vaccines against respiratory pathogens. To vaccinate against respiratory disease, pulmonary delivery is an attractive route because it mimics the route of natural infection and can confer both mucosal and systemic immunity. We have previously demonstrated that a single dose, intranasal vaccine based on polyanhydride nanoparticles elicited a protective immune response against Yersinia pestis for at least 40 weeks after immunization with F1-V. Herein, we investigate the effect of nanoparticle chemistry and its attributes on the kinetics and maturation of the antigen-specific serum antibody response. We demonstrate that manipulation of polyanhydride nanoparticle chemistry facilitated differential kinetics of development of antibody titers, avidity, and epitope specificity. The results provide new insights into the underlying role(s) of nanoparticle chemistry in providing long-lived humoral immunity and aid in the rational design of nanovaccine formulations to induce long-lasting and mature antibody responses.

Graphical abstract: Effect of nanovaccine chemistry on humoral immune response kinetics and maturation

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The article was received on 03 Jul 2014, accepted on 24 Sep 2014 and first published on 25 Sep 2014


Article type: Paper
DOI: 10.1039/C4NR03724C
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Citation: Nanoscale, 2014,6, 13770-13778
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    Effect of nanovaccine chemistry on humoral immune response kinetics and maturation

    S. L. Haughney, K. A. Ross, P. M. Boggiatto, M. J. Wannemuehler and B. Narasimhan, Nanoscale, 2014, 6, 13770
    DOI: 10.1039/C4NR03724C

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