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Issue 20, 2014
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Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

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Abstract

In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and grafted with gadolinium complexes having average sizes ranging from ca. 50 to 150 nm according to the siRNA/HSA composition. The non-covalent siRNA/HSA assembly is formed on isobutyramide-modified mesoporous silica and the self-supported HSA-based nanoparticles are obtained following the silica template dissolution. These original protein particles provide simultaneous magnetic resonance imaging contrast enhancement and cellular in vitro gene silencing.

Graphical abstract: Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

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Publication details

The article was received on 13 May 2014, accepted on 28 Jul 2014 and first published on 05 Aug 2014


Article type: Communication
DOI: 10.1039/C4NR02623C
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Citation: Nanoscale, 2014,6, 11676-11680
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    Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging

    D. Mertz, C. Affolter-Zbaraszczuk, J. Barthès, J. Cui, F. Caruso, T. F. Baumert, J. Voegel, J. Ogier and F. Meyer, Nanoscale, 2014, 6, 11676
    DOI: 10.1039/C4NR02623C

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