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Issue 13, 2014
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Versatile types of polysaccharide-based supramolecular polycation/pDNA nanoplexes for gene delivery

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Abstract

Different polysaccharide-based supramolecular polycations were readily synthesized by assembling multiple β-cyclodextrin-cored star polycations with an adamantane-functionalized dextran via host–guest interaction in the absence or presence of bioreducible linkages. Compared with nanoplexes of the starting star polycation and pDNA, the supramolecular polycation/pDNA nanoplexes exhibited similarly low cytotoxicity, improved cellular internalization and significantly higher gene transfection efficiencies. The incorporation of disulfide linkages imparted the supramolecular polycation/pDNA nanoplexes with the advantage of intracellular bioreducibility, resulting in better gene delivery properties. In addition, the antitumor properties of supramolecular polycation/pDNA nanoplexes were also investigated using a suicide gene therapy system. The present study demonstrates that the proper assembly of cyclodextrin-cored polycations with adamantane-functionalized polysaccharides is an effective strategy for the production of new nanoplex delivery systems.

Graphical abstract: Versatile types of polysaccharide-based supramolecular polycation/pDNA nanoplexes for gene delivery

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Supplementary files

Article information


Submitted
24 Mar 2014
Accepted
03 May 2014
First published
06 May 2014

Nanoscale, 2014,6, 7560-7569
Article type
Paper

Versatile types of polysaccharide-based supramolecular polycation/pDNA nanoplexes for gene delivery

Y. Hu, N. Zhao, B. Yu, F. Liu and F. Xu, Nanoscale, 2014, 6, 7560
DOI: 10.1039/C4NR01590H

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