Issue 16, 2014
From the journal:

Nanoscale

Plasmonic ELISA for the detection of gp120 at ultralow concentrations with the naked eye†‡

D. Cecchin,a   R. de la Rica,b   R. E. S. Bain,b   M. W. Finnis,c   M. M. Stevensb  and  G. Battaglia*a  

* Corresponding authors

a Department of Chemistry, The MRC/UCL Centre for Medical Molecular Virology, University College London, 20 Gordon Street, London, UK
E-mail: g.battaglia@ucl.ac.uk

b Department of Materials, Department of Bioengineering and Institute for Biomedical Engineering, Imperial College London, Exhibition Road, London, UK

c Thomas Young Centre, Department of Materials and Department of Physics, Imperial College London, Exhibition Road, London, UK

Abstract

The technique of plasmonic ELISA is utilised here to detect the HIV-1 protein gp120 with the ultralow limit of detection of 8 × 10−20 M (10−17 g mL−1) in an independent laboratory. It was corroborated that changes in the concentration of hydrogen peroxide as small as 0.05 μM could lead to nanoparticle solutions of completely different tonality.

Graphical abstract: Plasmonic ELISA for the detection of gp120 at ultralow concentrations with the naked eye

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Article information

DOI
https://doi.org/10.1039/C3NR06167A
Article type
Communication
Submitted
20 Nov 2013
Accepted
11 Apr 2014
First published
05 May 2014

Nanoscale, 2014,6, 9559-9562

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Plasmonic ELISA for the detection of gp120 at ultralow concentrations with the naked eye

D. Cecchin, R. de la Rica, R. E. S. Bain, M. W. Finnis, M. M. Stevens and G. Battaglia, Nanoscale, 2014, 6, 9559 DOI: 10.1039/C3NR06167A

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