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Issue 5, 2014
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Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

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Abstract

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.

Graphical abstract: Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

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Publication details

The article was received on 05 Nov 2013, accepted on 23 Dec 2013 and first published on 03 Jan 2014


Article type: Paper
DOI: 10.1039/C3NR05897B
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Citation: Nanoscale, 2014,6, 2929-2936
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    Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

    D. Staedler, T. Magouroux, S. Passemard, S. Schwung, M. Dubled, G. S. Schneiter, D. Rytz, S. Gerber-Lemaire, L. Bonacina and J. Wolf, Nanoscale, 2014, 6, 2929
    DOI: 10.1039/C3NR05897B

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