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Issue 10, 2014
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Fungal polyketide biosynthesis – a personal perspective

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Abstract

This Viewpoint article provides a personal viewpoint of research in the area of fungal polyketide biosynthesis. It spans the period from the first applications and subsequent development of modern stable-isotope labelling methods, the isolation, sequencing and expression of PKS genes, biochemical and structural characterisation of PKS domains, fungal genome sequencing, through to genetic engineering of whole pathways. This article forms part of a “trilogy” of related Viewpoints from three close contemporaries who have been privileged to share in these developments since their outset over forty years ago and to enjoy both professional and personal interactions throughout that time.

Graphical abstract: Fungal polyketide biosynthesis – a personal perspective

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Article information


Submitted
19 May 2014
First published
23 Jul 2014

Nat. Prod. Rep., 2014,31, 1247-1252
Article type
Viewpoint

Fungal polyketide biosynthesis – a personal perspective

T. J. Simpson, Nat. Prod. Rep., 2014, 31, 1247
DOI: 10.1039/C4NP00065J

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