Issue 11, 2014

Recent advances in the field of bioactive tetronates


Covering: up to mid-2014

Over the last several decades, the number of pharmacologically active natural products has significantly increased and several natural product families have taken shape. This review highlights the family of tetronate and spirotetronate compounds, which show a vast structural and functional diversity. The rapid growth of this group has created the need for a comprehensive overview and classification system, which we have devised based on structural characteristics. An updated overview is provided based on known tetronates, intended to spur further research in this field by identifying common structural features and general principles of their biosynthesis. We also compare a selection of chemical syntheses of representative compounds belonging to individual subtypes, both in terms of their efficiency as well as the extent to which they are biomimetic. This review also summarizes progress in unraveling some of the principles underlying the potent and varied bioactivities of natural tetronate antibiotics, and in identifying and better understanding their structure–activity relationships and modes of action.

Graphical abstract: Recent advances in the field of bioactive tetronates

Article information

Article type
Review Article
07 Feb 2014
First published
25 Jun 2014
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2014,31, 1554-1584

Recent advances in the field of bioactive tetronates

L. Vieweg, S. Reichau, R. Schobert, P. F. Leadlay and R. D. Süssmuth, Nat. Prod. Rep., 2014, 31, 1554 DOI: 10.1039/C4NP00015C

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