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Issue 9, 2014
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Chemistry of silybin

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Abstract

Covering: 1959 to 2013

Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared.

Graphical abstract: Chemistry of silybin

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Article information


Submitted
15 Nov 2013
First published
30 Jun 2014

Nat. Prod. Rep., 2014,31, 1138-1157
Article type
Review Article
Author version available

Chemistry of silybin

D. Biedermann, E. Vavříková, L. Cvak and V. Křen, Nat. Prod. Rep., 2014, 31, 1138
DOI: 10.1039/C3NP70122K

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