Issue 1, 2014

Industrial natural product chemistry for drug discovery and development

Abstract

Covering: up to March 2013

In addition to their prominent role in basic biological and chemical research, natural products are a rich source of commercial products for the pharmaceutical and other industries. Industrial natural product chemistry is of fundamental importance for successful product development, as the vast majority (ca. 80%) of commercial drugs derived from natural products require synthetic efforts, either to enable economical access to bulk material, and/or to optimize drug properties through structural modifications. This review aims to illustrate issues on the pathway from lead to product, and how they have been successfully addressed by modern natural product chemistry. It is focused on natural products of current relevance that are, or are intended to be, used as pharmaceuticals.

Graphical abstract: Industrial natural product chemistry for drug discovery and development

Article information

Article type
Review Article
Submitted
01 Jul 2013
First published
21 Oct 2013

Nat. Prod. Rep., 2014,31, 35-60

Industrial natural product chemistry for drug discovery and development

A. Bauer and M. Brönstrup, Nat. Prod. Rep., 2014, 31, 35 DOI: 10.1039/C3NP70058E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements