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Issue 2, 2015
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Chemo-enzymatic Baeyer–Villiger oxidation in the presence of Candida antarctica lipase B and ionic liquids

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Abstract

A new method for the chemo-enzymatic Baeyer–Villiger oxidation of cyclic ketones to lactones has been developed. The influence of reaction parameters and the structure of various ionic liquids were studied. Free Candida antarctica lipase B or Novozyme-435 suspended in an ionic liquid was used as the catalytic phase. The reaction was carried out under mild conditions at room temperature using 30% aq. H2O2 as the oxidation agent. 1-Butyl-3-methyl bistriflimide was the most effective ionic liquid and increased the reaction rate compared to toluene. Lipase exhibited good stability, and the ionic liquid could be easily reused. Therefore, a general chemo-enzymatic method for the oxidation of cyclohexanones and cyclobutanones to obtain adequate lactones in high yields (79–95%) has been proposed.

Graphical abstract: Chemo-enzymatic Baeyer–Villiger oxidation in the presence of Candida antarctica lipase B and ionic liquids

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Article information


Submitted
06 Nov 2014
Accepted
28 Nov 2014
First published
02 Dec 2014

New J. Chem., 2015,39, 1315-1321
Article type
Paper
Author version available

Chemo-enzymatic Baeyer–Villiger oxidation in the presence of Candida antarctica lipase B and ionic liquids

A. Drożdż, K. Erfurt, R. Bielas and A. Chrobok, New J. Chem., 2015, 39, 1315
DOI: 10.1039/C4NJ01976H

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